Glowing Stem Cells May Help Repair Damaged Hearts

Glowing Stem Cells May Help Repair Damaged Hearts
Tuesday, 28 September 2010

Stem cells that glow like fireflies could someday help doctors heal damaged hearts without cutting into patients' chests.

In his University of Central Florida lab, Steven Ebert, an associate professor in UCF's College of Medicine, engineered stem cells with the same enzyme that makes fireflies glow. The "firefly" stem cells glow brighter and brighter as they develop into healthy heart muscle, allowing doctors to track whether and where the stem cells are working.

Researchers are keenly interested in stem cells because they typically morph into the organs where they are transplanted. But why and how fast they do it is still a mystery. Now Ebert's cells give researchers the ability to see the cells in action with the use of a special camera lens that picks up the glow under a microscope.

"The question that we answered was, 'How do you follow these cells in the lab and find out where they're going?'" said Ebert.

If doctors can figure out exactly how the cells repair and regenerate cardiac tissue, stem cell therapies could offer hope to more than 17.6 million Americans who suffer from coronary disease. The glow of the enzyme also means therapies would no longer require cutting into patients' chest cavities to monitor the healing.

Now that scientists can track the stem cells, Ebert said he hopes to use them in disease models to determine how they heal a damaged heart and what conditions are most suitable for the stems cells to thrive.

Source: University of Central Florida
Contact: Zenaida Gonzalez Kotala

Reference:
Generation of Novel Reporter Stem Cells and Their Application for Molecular Imaging of Cardiac-Differentiated Stem Cells In Vivo
Ramana K. Kammili, David G. Taylor, Jixiang Xia, Kingsley Osuala, Kellie Thompson, Donald R. Menick, Steven N. Ebert
Stem Cells and Development. September 2010, 19(9): 1437-1448, doi:10.1089/scd.2009.0308
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ZenMaster

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