New roles emerge for non-coding RNAs
in directing embryonic development
Monday, 29 August 2011
lincRNAs orchestrate the fate of embryonic
stem cells (shown here) by keeping them in
their fledgling state or directing them along
the path to cell specialization.
Image courtesy of Alex Meissner.
Broad scientists discovered several years ago that the human and mouse genomes encode thousands of unusual RNAs — termed large, intergenic non-coding RNAs (lincRNAs) — but their role was almost entirely unknown. By studying more than 100 lincRNAs in ES cells, the researchers now show that these RNAs help regulate development by physically interacting with proteins to coordinate gene expression and suggest that lincRNAs may play similar roles in most cells.
Mitchell Guttman, Julie Donaghey, Bryce W. Carey, Manuel Garber, Jennifer K. Grenier, Glen Munson, Geneva Young, Anne Bergstrom Lucas, Robert Ach, Laurakay Bruhn, Xiaoping Yang, Ido Amit, Alexander Meissner, Aviv Regev, John L. Rinn, David E. Root & Eric S. Lander
Nature. August 28, 2011 DOI: 10.1038/nature10398
CellNEWS - Tuesday, 14 July 2009