Noted authorities explore these questions in special issue of Translational Research
- Bone marrow and circulating stem/progenitor cells for regenerative cardiovascular therapy
Mohamad Amer Alaiti, Masakazu Ishikawa, and Marco A. Costa
Despite initial promising pilot studies, only small improvements in a few clinical outcomes have been seen using stem cell therapies to treat heart disease in the acute or chronic setting. But new research, and a multitude of new pilot studies, may alter this scenario.
- New therapies for the failing heart: trans-genes versus trans-cells
Vincenzo Lionetti, and Fabio A. Recchia
This review presents key aspects of cardiac gene therapy and stem cell therapy for the failing heart. Recent discoveries in stem cell biology may revitalize gene therapy and, vice versa.
- Endothelial lineage cell as a vehicle for systemic delivery of cancer gene therapy
Arkadiusz Z. Dudek
Rather than focusing on the cancer cell itself, attention to blood vessels feeding the cancerous cells, lined by endothelial cells, presents a new avenue of cancer therapy. The author discusses recent evidence that endothelial progenitor cells may be useful in treating primary and metastatic tumours. Targeted cancer gene therapy using endothelial lineage cells to target tumour sites and produce a therapeutic protein has proven feasible.
- Pluripotent stem cell-derived natural killer cells for cancer therapy
David A. Knorr, and Dan S. Kaufman
The potential value as well as challenges of using human embryonic stem cells and induced pluripotent stem cells is to provide platforms for new cell-based therapies to treat malignant diseases are discussed.
- Translation of stem cell therapy for neurological diseases
Sigrid C. Schwarz, and Johannes Schwarz
Early clinical work to develop cell-based therapy for neurologic disorders such as Parkinson's disease is discussed.
- Stem cell technology for the treatment of acute and chronic renal failure
Christopher J. Pino, and H. David Humes
The authors cover the relative potential and success to date of embryonic or induced pluripotent stem cells as therapies for regenerating functional kidney tissue.
- Stem cell approaches for the treatment of type 1 diabetes mellitus
Ryan T. Wagner, Jennifer Lewis, Austin Cooney, and Lawrence Chan
The authors provide a thorough discussion of the potential of using either embryonic stem cells or induced pluripotent stem cells to generate functional islet cells, the cells of the pancreas which normally make insulin, but fail to do so in severe forms of diabetes.
- Intestinal stem cells and epithelial–mesenchymal interactions in the crypt and stem cell niche Anisa Shaker, and Deborah C. Rubin
Both preclinical and early clinical trials have been carried out with allogeneic bone marrow-derived mesenchymal stem cells to treat steroid refractory acute and chronic inflammatory bowel diseases, particularly Crohn's disease.
- Stem cells and cell therapy approaches in lung biology and diseases
Viranuj Sueblinvong, and Daniel J. Weiss,
Cell-based therapies with embryonic or adult stem cells have emerged as potential novel approaches for several devastating and otherwise incurable lung diseases, including emphysema, pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome.
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